Asian Journal of Research in Chemistry

R. C. Patel ¹, C. N. Patel ¹, B. B. Panigrahi ¹, V. H. Bhaskar ¹

Affiliations
1 Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, IN

Abstract

Some New benzhydryl piperazine sulfonamide and carboxamide is synthesized from benzaldehyde and phenyl magnesium chloride (Grignard Reagent) under nitrogen atmosphere to give benzhydrol which on treating with thionyl chloride give corresponding benzhydryl chloride which is directly treated with piperazine and anhydrous potassium carbonate using DMF as solvent to give corresponding 1-benzhydryl piperazine. The nucleophilic substitution reaction of 1-benzhydryl piperazine with different substituted aromatic sulfonyl chloride and acid chloride in presence of triethylamine and dichloromethane to give corresponding benzhydryl piperazine sulfonamide and carboxamide. All the title compounds characterised on the basis of their IR, MASS, ¹H NMR spectroscopic data analysis.

Keywords

Benzhydrol, Acid Chloride, Sulfonyl Chloride, Antimicrobial Screening.

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P. B. Mohite ¹, R. B. Pandhare ¹, S. G. Khanage ¹, V. H. Bhaskar ²

Affiliations
1 M.E.S. College of Pharmacy, Sonai-414105, Ahmednagar, Maharashtra, IN
2 MP Patel College of Pharmacy, Kapadwanj, Gujarat, IN

Abstract

A simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Tranexamic acid in bulk and pharmaceutical dosage formulations. The developed method is based on the formation of condensation product of drug with ferric chloride and potassium ferricynide, which shows absorbance maximum at 710 nm. The proposed method showed linearity in the range of 2-20 ug/ml. Results were statistically validated and were found to be reproducible. Recovery studies indicate that the method is accurate.

Keywords

Tranexamic Acid, Ferric Chloride, Potassium Ferricyanide, Spectrophotometric Method.

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V. H. Bhaskar ¹, M. Kumar ², B. R. Balakrishnan ², B. Sangameswaran ²

Affiliations
1 M.P. Patel College of Pharmacy, Kapadwanji, Gujarat-3876202, IN
2 Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, IN

Abstract

Certain (2E)-substituted-2-ethylidene-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-(2H)-ones (4a-f) have been synthesized by the condensation of 4,5-diphenylimidazoin-2-thiones (3) with different aromatic aldehydes and chloroacetic acid in presence of acetic anhydride, anhydrous sodium acetate and glacial acetic acid. These compounds were characterized by their analytical and spectral data. The title compounds were found to be efficient antibacterial agents on evaluation.

Keywords

Imidazothiazole, Biological Activity, Antibacterial Activity.

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